Just booked flight and hotel for Napa, CA...

[bobarian]

Wine, Food, scenic? Hard to give advice unless you specify your likes/dislikes. Traveling with family? Wife? Kids?

I'll assume your flying in to San Francisco and then driving to Napa? Where are you staying? Access to a car?

Most wineries will be in harvest that time of year depending on the type of grape and the weather. Most require appointments as well.