Do you have a good draft going through the place? If so it can be done. I smoked in my last house when I was married and the wife was on a trip. Smell was gone in three days. I smoked by a window though. At my bachelor party we weren't smoking in the house but all the smoke came in through the garage into tha house as if there were five people smoking in the house. It cleared out pretty quickly, four or five days.
Just do it, she'll deal.
Just make sure to close her bedroom door.