I've experienced flavor changes between a robusto and toro of the Pepin Blue. The toro was "peppier"...like licking a pepper grinder. The robusto, not so much.
Asides from my experiences, I've HEARD that bigger RG's give you more flavor, but to me the wrapper is a vital part of the equation. Having a huge RG will lessen the wrappers impact on the final flavor, AND sometimes requires more effort to keep it burning right.