I love my Glock 27. Glocks aren't for everyone though. I would also say that you should stick with whatever caliber you can handle. What I mean by that is if you can group a 9 mm very well and only soso with a .40 or .45 then stick with the 9 mmm. I know you can practice, but if you can put 10 shots in a tight group then that's better than 10 shots from a bigger caliber spread out.
Jumping on the bandwagon as well about the safety of the Glock, trigger pull equals fire, no trigger pull no fire.